linoleate (18:2n6) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs388891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.163
Position:
131700794
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-10.133
Reference Allele:
G
-log10(P):
-53.888
MAF:
0.294
Beta (Num):
-0.033
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid oxidation, carnitine shuttle.6[1], 7[2]

Ratio Explanation:

The ratio reflects the balance between linoleate, an essential fatty acid, and oleoylcarnitine, which requires the SLC22A5-mediated carnitine shuttle for its formation during fatty acid transport.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered function of the carnitine transporter *SLC22A5* disrupts carnitine-dependent fatty acid oxidation, affecting the ratio. This impaired energy metabolism likely impacts hematopoiesis, leading to the associated changes in neutrophil, platelet, and other blood cell counts, as carnitine levels influence immune cell function.8[1]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data