arachidonate (20:4n6) to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs272880

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.139
Position:
131670178
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-8.400
Reference Allele:
T
-log10(P):
-37.646
MAF:
0.294
Beta (Num):
-0.065
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.074
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid metabolism, eicosanoid synthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid oxidation, carnitine shuttle.2[1], 7[2]

Ratio Explanation:

The ratio may reflect carnitine shuttle efficiency for fatty acid oxidation (denominator) relative to arachidonate metabolism (numerator), potentially modulated by the carnitine transporter SLC22A5.1[1], 7[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC22A5 carnitine transporter function likely dysregulates fatty acid oxidation, impacting energy for hematopoiesis. This may affect the proliferation and differentiation of immune cells, leading to observed changes in monocyte, platelet, and other white blood cell counts.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data