branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to oleoylcarnitine (c18:1)

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs388891

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.158
Position:
131700794
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-10.548
Reference Allele:
G
-log10(P):
-58.220
MAF:
0.294
Beta (Num):
-0.028
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine transport4[1], 5[2], 6[3]

Ratio Explanation:

The ratio reflects carnitine-dependent fatty acid transport. Reduced SLC22A5 function can decrease oleoylcarnitine formation and alter the broader fatty acid pool.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the carnitine transporter SLC22A5 can impair fatty acid oxidation, altering the metabolic ratio and leading to changes in hematological traits due to disturbed energy metabolism in hematopoietic cells.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data