docosapentaenoate n3 DPA; 22:5n3 to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs10076701

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
-0.171
Position:
131596419
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-10.896
Reference Allele:
C
-log10(P):
-61.988
MAF:
0.445
Beta (Num):
-0.052
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
PDLIM4 P4HA2 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid metabolism

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

The ratio may reflect altered fatty acid metabolism and transport, where SLC22A4/5 variants could impact carnitine-dependent transport of fatty acids for oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A4/SLC22A5 can alter carnitine transport, affecting fatty acid oxidation and uric acid levels. This dysregulation, potentially reflected in the DPA to 3-hydroxyoleoylcarnitine ratio, is linked to gout and inflammation, influencing neutrophil and platelet counts.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:SLC22A4/SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data