margaroylcarnitine (c17)* to tridecenedioate (c13:1-dc)*

Numerator Metabolite

Structure of margaroylcarnitine (c17)*
Metabolite Accession: GCST90199929
Name: margaroylcarnitine (c17)*
Hmdb Id: HMDB0006210
Super Pathway: NA
Sub Pathway: NA
Inchikey: DWSFAVOTORHAAL

Denominator Metabolite

Metabolite Accession: GCST90199867
Name: tridecenedioate (c13:1-dc)*
Hmdb Id: HMDB02327
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs272855

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.142
Position:
131687175
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
9.201
Reference Allele:
T
-log10(P):
-44.789
MAF:
0.294
Beta (Num):
0.096
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.046
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 C5orf56 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism (acylcarnitine).4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects altered fatty acid transport and metabolism; decreased SLC22A5 function may increase C17-carnitine while compensatory omega-oxidation increases tridecenedioate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 transporter function alters fatty acid metabolism, reflected by the C17/C13:1-DC ratio. This impaired energy metabolism, particularly affecting immune cells which rely on fatty acid oxidation, likely contributes to the observed alterations in monocyte, lymphocyte, and other blood cell counts.10[1], 11[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data