eicosapentaenoate (epa; 20:5n3) to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.183
Position:
131690241
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-10.005
Reference Allele:
G
-log10(P):
-52.588
MAF:
0.373
Beta (Num):
-0.065
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.117
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
11.0
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Eicosanoid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the balance between eicosapentaenoate availability and its metabolism relative to the transport of long-chain fatty acids via the SLC22A5 carnitine transporter.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function impairs carnitine-dependent fatty acid transport, altering cellular energy and lipid metabolism. This directly impacts urate excretion, also mediated by SLC22A5, and may lead to systemic effects on hematological cell counts and overall growth (height).10[1], 11[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data