myristoleoylcarnitine (c14:1)* to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs2999545

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.160
Position:
151904146
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
14.770
Reference Allele:
T
-log10(P):
-112.001
MAF:
0.389
Beta (Num):
0.039
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.121
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs57548703

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Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.194
Position:
74047148
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
8.118
Reference Allele:
A
-log10(P):
-35.287
MAF:
0.052
Beta (Num):
0.068
Novel Locus:
Yes ✔️
SE (Num):
0.033
Beta (Den):
-0.126
SE (Den):
0.033
No CNV overlap
rQTL cluster:
42
Reaction Distance:
NA
Closest Genes:
ACOT2 ACOT4 HEATR4 ACOT6 ACOT1

Region: rs388891

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.096
Position:
131700794
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
8.288
Reference Allele:
G
-log10(P):
-36.698
MAF:
0.295
Beta (Num):
0.073
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.023
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis/omega-oxidation5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of myristoleoylcarnitine to tetradecadienoate may reflect the balance between fatty acid beta-oxidation and fatty acid biosynthesis/desaturation, modulated by ACOT1 activity on shared acyl-CoA precursors.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in ACOT1 likely alters fatty acid metabolism, as reflected by the metabolite ratio.8[1], 9[2] Given that fatty acid metabolism is crucial for hematopoietic stem cell function, this dysregulation can impact the production of monocytes, platelets, and other blood cells.10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:ACOT1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data