margarate (17:0) to Hexanoylcarnitine

Numerator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs274555

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.137
Position:
131722951
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-9.222
Reference Allele:
C
-log10(P):
-44.979
MAF:
0.407
Beta (Num):
-0.042
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.095
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of margarate to hexanoylcarnitine reflects the balance between long-chain fatty acids and the products of incomplete medium-chain fatty acid beta-oxidation.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced ACADM function impairs fatty acid oxidation, leading to altered energy metabolism.3[1], 9[2] This dysregulation is linked to changes in purine metabolism, which can increase uric acid levels and the risk of gout.10[3], 11[4]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data