adrenate (22:4n6) to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs273917

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.128
Position:
131659618
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-8.247
Reference Allele:
G
-log10(P):
-36.360
MAF:
0.294
Beta (Num):
-0.054
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.074
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 SLC22A5 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine transport.6[1], 7[2]

Ratio Explanation:

The ratio may indicate an imbalance between polyunsaturated fatty acid availability and their transport into mitochondria for beta-oxidation, potentially modulated by carnitine transporter function.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A5 can impair carnitine transport, disrupting fatty acid oxidation and cellular energy balance. This systemic metabolic disruption, reflected by the metabolite ratio, likely impacts the development and function of hematopoietic cells, leading to altered blood cell counts, including monocytes and platelets.1[1], 8[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data