arachidonate (20:4n6) to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs388891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.189
Position:
131700794
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-10.388
Reference Allele:
G
-log10(P):
-56.529
MAF:
0.294
Beta (Num):
-0.064
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.125
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
9.0
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Eicosanoid synthesis, omega-6 fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid transport, beta-oxidation.7[1], 8[2]

Ratio Explanation:

This ratio may reflect the balance between pro-inflammatory arachidonate signaling and fatty acid oxidation, with SLC22A5 dysfunction potentially increasing the ratio by decreasing palmitoylcarnitine.2[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function impairs fatty acid oxidation, altering energy metabolism and potentially inflammatory signaling. This systemic effect, reflected in the ratio, likely impacts hematopoietic cell production and function, leading to observed changes in monocyte, platelet, and other blood cell counts.9[1], 10[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data