docosapentaenoate n3 DPA; 22:5n3 to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.176
Position:
131690241
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-10.879
Reference Allele:
G
-log10(P):
-61.792
MAF:
0.373
Beta (Num):
-0.059
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.117
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid metabolism5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation7[1], 8[2], 9[3]

Ratio Explanation:

This ratio may reflect cellular carnitine status and fatty acid metabolism, as SLC22A5 mediates carnitine uptake required for palmitoylcarnitine's transport into mitochondria.1[1], 7[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine uptake, affecting fatty acid oxidation and leading to inflammatory responses and altered immune cell counts, including neutrophils, eosinophils, and lymphocytes.1[1], 3[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data