docosahexaenoylcarnitine (c22:6)* to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Metabolite Accession: GCST90200146
Name: docosahexaenoylcarnitine (c22:6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs270607

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.155
Position:
131649186
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
8.529
Reference Allele:
G
-log10(P):
-38.758
MAF:
0.309
Beta (Num):
0.114
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
-0.041
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport, beta-oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects the carnitine-dependent conversion of DHA to its acylcarnitine for mitochondrial transport, a process reliant on the SLC22A5 carnitine transporter.1[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair fatty acid oxidation, the primary energy source for immune cells. This impairment likely alters the proliferation and maintenance of hematopoietic cell lineages, leading to the observed associations with monocyte, lymphocyte, and white blood cell counts.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data