tetradecadienoate (14:2)* to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs2999545

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.176
Position:
151904146
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-15.608
Reference Allele:
T
-log10(P):
-124.785
MAF:
0.389
Beta (Num):
-0.121
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.055
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs388891

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.115
Position:
131700794
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
-9.528
Reference Allele:
G
-log10(P):
-47.886
MAF:
0.295
Beta (Num):
-0.023
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle

Ratio Explanation:

The ratio likely reflects the balance between free fatty acid availability and their transport into mitochondria for oxidation, which is dependent on the carnitine transporter SLC22A5.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine transport, disrupting fatty acid oxidation and causing accumulation of lipids.4[1] This metabolic disruption in hematopoietic cells could alter cell membrane integrity and energy production, leading to observed changes in blood cell counts.5[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data