hexadecadienoate (16:2n6) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs388891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.172
Position:
131700794
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-10.654
Reference Allele:
G
-log10(P):
-59.353
MAF:
0.295
Beta (Num):
-0.043
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine transport.11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

The ratio reflects cellular carnitine uptake efficiency; lower SLC22A5 function decreases oleoylcarnitine (a long-chain acylcarnitine) relative to other fatty acids like hexadecadienoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired SLC22A5 function alters carnitine-dependent fatty acid metabolism.15[1], 16[2], 6[3] This dysregulation affects the maturation and function of various hematopoietic cell lineages, including monocytes, lymphocytes, and platelets, leading to the observed changes in their counts.17[4], 18[5], 19[6], 20[7], 21[8], 22[9], 23[10], 24[11]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data