oleoylcarnitine (c18:1) to eicosenoate (20:1)

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.153
Position:
131720265
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
10.190
Reference Allele:
G
-log10(P):
-54.472
MAF:
0.294
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.024
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle

Denominator Metabolite Explanation:

Fatty acid elongation

Ratio Explanation:

The ratio reflects cellular carnitine uptake capacity versus fatty acid chain elongation. Impaired SLC22A5 function may elevate oleoylcarnitine due to reduced transport.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function, as indicated by eQTL colocalization, likely impairs carnitine-dependent fatty acid import into mitochondria for beta-oxidation. This can lead to an accumulation of acylcarnitines like oleoylcarnitine and potentially influence cellular processes and counts of various blood cells, including monocytes and platelets.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data