myristoleoylcarnitine (c14:1)* to hexadecadienoate (16:2n6)

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Associated Genomic Regions

Region: rs270612

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.119
Position:
131637338
SE (Ratio):
0.015
Effect Allele:
G
Z-score (Ratio):
7.868
Reference Allele:
A
-log10(P):
-33.254
MAF:
0.292
Beta (Num):
0.073
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.046
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport, Carnitine shuttle

Denominator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.4[1], 5[2]

Ratio Explanation:

The ratio of myristoleoylcarnitine to hexadecadienoate may reflect the efficiency of carnitine-dependent fatty acid transport relative to the availability of other fatty acids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 expression likely modifies carnitine transport, affecting the myristoleoylcarnitine to hexadecadienoate ratio. Impaired carnitine metabolism and fatty acid oxidation can impact hematopoiesis, leading to observed changes in blood cell counts like monocyte and platelet levels.6[1]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data