3-hydroxyoleoylcarnitine to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.162
Position:
131690241
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
9.667
Reference Allele:
G
-log10(P):
-49.231
MAF:
0.374
Beta (Num):
0.108
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.054
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Xenobiotic metabolism, Amino acid metabolism

Ratio Explanation:

The ratio may reflect the transport activity of SLC22A4/A5, where 3-hydroxyoleoylcarnitine is a known substrate and the glutamine conjugate is a potential substrate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in SLC22A4/SLC22A5 alter carnitine transport, affecting fatty acid oxidation and systemic energy metabolism. This dysfunction plausibly connects to hematological phenotypes like neutrophil and platelet counts through impacts on cell function and development, and to uric acid levels via renal transport.2[1], 4[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data