linolenoylcarnitine (c18:3)* to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs274561

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.137
Position:
131719228
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
9.871
Reference Allele:
C
-log10(P):
-51.246
MAF:
0.373
Beta (Num):
0.098
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.039
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects carnitine availability for the esterification of linolenate, a process modulated by the carnitine transporter SLC22A5 for mitochondrial import.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC22A5/SLC22A4 alters transporter function, impacting both carnitine-dependent fatty acid metabolism (the ratio) and renal urate transport.9[1], 10[2] This pleiotropic effect likely explains the colocalization with gout and the association with uric acid levels.10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data