palmitoleoylcarnitine (c16:1)* to margarate (17:0)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.206
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-11.618
Reference Allele:
G
-log10(P):
-70.178
MAF:
0.176
Beta (Num):
-0.130
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.076
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs635619

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.136
Position:
131720265
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
9.196
Reference Allele:
G
-log10(P):
-44.742
MAF:
0.294
Beta (Num):
0.092
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.045
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis

Ratio Explanation:

The ratio may reflect the balance between fatty acid transport for oxidation (palmitoleoylcarnitine) and fatty acid availability (margarate), influenced by carnitine transport efficiency.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine-dependent fatty acid transport into mitochondria, altering fatty acid metabolism.3[1], 4[2] This dysregulation may contribute to the lipid abnormalities and increased cardiovascular risk observed in phenotypes like coronary atherosclerosis and hypercholesterolemia.6[3], 7[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data