5-dodecenoate (12:1n7) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.158
Position:
102075479
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-9.415
Reference Allele:
G
-log10(P):
-46.797
MAF:
0.176
Beta (Num):
-0.112
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.046
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs270615

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.138
Position:
131641573
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-9.707
Reference Allele:
C
-log10(P):
-49.621
MAF:
0.292
Beta (Num):
-0.020
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.117
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/elongation

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

The ratio of 5-dodecenoate to myristoylcarnitine may reflect the balance between fatty acid synthesis/modification and mitochondrial fatty acid oxidation, influenced by carnitine transport.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair fatty acid oxidation, leading to lipid accumulation and metabolic dysregulation, which are risk factors for coronary atherosclerosis and hypercholesterolemia.1[1], 2[2], 3[3], 6[4], 7[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data