10-heptadecenoate (17:1n7) to acetylcarnitine (c2)

Numerator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs419291

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.145
Position:
131633355
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
-10.152
Reference Allele:
C
-log10(P):
-54.088
MAF:
0.372
Beta (Num):
-0.033
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid oxidation, TCA cycle5[1], 6[2]

Ratio Explanation:

An elevated ratio suggests impaired carnitine-dependent transport or fatty acid oxidation, as SLC22A5 dysfunction can decrease acetylcarnitine levels and affect fatty acid metabolism.3[1], 5[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine transport, impacting fatty acid oxidation and energy metabolism.1[1], 3[2], 7[3] This disruption, reflected in the metabolite ratio, may associate with altered immune cell counts and uric acid levels due to systemic metabolic stress.8[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data