10-nonadecenoate (19:1n9) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.150
Position:
131720265
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-10.147
Reference Allele:
G
-log10(P):
-54.029
MAF:
0.294
Beta (Num):
-0.034
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.116
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty Acid Beta-Oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

A lower SLC22A5 function likely impairs myristoylcarnitine generation and fatty acid transport, potentially leading to an accumulation of fatty acids like 10-nonadecenoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function, associated with impaired carnitine transport, may alter fatty acid metabolism.10[1], 11[2] This dysregulation could impact hematopoietic cell functions, given SLC22A5 expression on these cells, potentially influencing their counts (e.g., monocyte, platelet, WBC) as observed in the associated phenotypes.12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data