adrenate (22:4n6) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs272855

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.183
Position:
131687175
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-11.065
Reference Allele:
T
-log10(P):
-63.858
MAF:
0.294
Beta (Num):
-0.053
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 C5orf56 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid elongation / Linoleic acid metabolism6[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation / Carnitine shuttle7[1], 8[2], 9[3]

Ratio Explanation:

This ratio may reflect the balance between fatty acid elongation/inflammation and fatty acid oxidation, modulated by SLC22A5's role in carnitine-dependent transport.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC22A4/SLC22A5 transporter function likely impacts carnitine-dependent fatty acid metabolism and ergothioneine transport, contributing to changes in hematopoietic cell function and counts (monocytes, platelets, WBCs).10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data