oleoylcarnitine (c18:1) to palmitate (16:0)

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.163
Position:
131720265
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
10.078
Reference Allele:
G
-log10(P):
-53.330
MAF:
0.294
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.034
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.5[1], 6[2]

Ratio Explanation:

The ratio reflects carnitine-dependent fatty acid transport (oleoylcarnitine) relative to a major free fatty acid (palmitate), influenced by SLC22A5-mediated carnitine uptake.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function disrupts cellular carnitine levels, impacting fatty acid oxidation, a key energy source for hematopoietic cells.7[1], 8[2], 9[3] This dysregulation likely underlies the observed associations with various blood cell counts, including neutrophil and platelet counts, and other systemic phenotypes like height.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data