dihomo-linoleate (20:2n6) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.146
Position:
102075479
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
9.048
Reference Allele:
G
-log10(P):
-43.369
MAF:
0.176
Beta (Num):
0.016
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.130
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs635619

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.137
Position:
131720265
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-10.145
Reference Allele:
G
-log10(P):
-54.013
MAF:
0.294
Beta (Num):
-0.045
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism5[1]

Denominator Metabolite Explanation:

Fatty acid oxidation6[1], 7[2], 8[3], 9[4]

Ratio Explanation:

The ratio reflects carnitine-dependent transport efficiency. Lower SLC22A5 activity decreases palmitoleoylcarnitine (denominator), increasing the ratio and indicating impaired fatty acid oxidation.1[1], 3[2], 7[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function impairs carnitine-dependent fatty acid transport for oxidation, altering lipid balance.1[1], 7[2] This metabolic disruption, indicated by the increased ratio, likely contributes to the development of atherosclerosis, ischemic heart disease, and related lipid disorders by affecting cardiac energy metabolism.2[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data