oleoylcarnitine (c18:1) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
0.163
Position:
131720265
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
10.443
Reference Allele:
G
-log10(P):
-57.107
MAF:
0.294
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.034
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects carnitine-dependent fatty acid transport versus the free fatty acid pool, directly influenced by the carnitine transporter function of SLC22A5.1[1], 3[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the `SLC22A5` carnitine transporter likely alters fatty acid metabolism.2[1], 8[2] This systemic metabolic shift may influence the development and maturation of hematopoietic stem cells, leading to observed variations in neutrophil, platelet, and other blood cell counts.9[3], 10[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data