10-nonadecenoate (19:1n9) to acetylcarnitine (c2)

Numerator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs274546

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.145
Position:
131699867
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-10.453
Reference Allele:
G
-log10(P):
-57.214
MAF:
0.373
Beta (Num):
-0.033
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Carnitine shuttle, fatty acid beta-oxidation.4[1], 7[2], 8[3]

Ratio Explanation:

A higher ratio suggests decreased carnitine transport by SLC22A5, leading to lower acetylcarnitine levels and consequently impaired oxidation of fatty acids like 10-nonadecenoate.2[1], 3[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A5 and SLC22A4, which are carnitine transporters, can alter carnitine-dependent fatty acid metabolism.1[1], 10[2], 11[3] This dysregulation affects cellular energy and may manifest as changes in immune cell counts (neutrophils, eosinophils) and levels of metabolic byproducts like uric acid.12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data