adrenate (22:4n6) to acetylcarnitine (c2)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs274556

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.167
Position:
131722075
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-10.324
Reference Allele:
A
-log10(P):
-55.860
MAF:
0.294
Beta (Num):
-0.053
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.114
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid metabolism, fatty acid biosynthesis.6[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio of adrenate to acetylcarnitine may reflect the balance between fatty acid availability and its beta-oxidation, influenced by carnitine transport via SLC22A5.5[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A5 can impair carnitine transport, disrupting fatty acid oxidation necessary for normal hematopoietic cell development and function.10[1], 11[2], 12[3] This disruption may lead to altered blood cell counts, including neutrophil and platelet levels.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data