arachidonate (20:4n6) to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs273917

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.174
Position:
131659618
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-8.788
Reference Allele:
G
-log10(P):
-41.029
MAF:
0.294
Beta (Num):
-0.065
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 SLC22A5 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Eicosanoid synthesis, inflammation.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.1[1], 2[2], 8[3]

Ratio Explanation:

The ratio of arachidonate to linolenoylcarnitine may reflect a balance between inflammatory signaling and carnitine-dependent fatty acid oxidation, which is modulated by SLC22A5 activity.1[1], 2[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function impairs carnitine uptake and fatty acid oxidation, altering the ratio. This systemic metabolic disruption likely affects the proliferation and differentiation of hematopoietic stem cells and overall growth, leading to the observed associations with various blood cell counts and height.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:[SLC22A5]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data