cis-3,4-methyleneheptanoylcarnitine to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Metabolite Accession: GCST90200266
Name: cis-3,4-methyleneheptanoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs2073644

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
-0.161
Position:
131723289
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-9.873
Reference Allele:
A
-log10(P):
-51.260
MAF:
0.448
Beta (Num):
-0.069
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.091
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.5[1]

Ratio Explanation:

The ratio likely reflects competitive transport of these two acylcarnitines by the SLC22A4/A5 transporters, indicating altered carnitine and fatty acid metabolism.1[1], 2[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered function of SLC22A4, an immune-expressed cation transporter, may impact immune cell function through changes in carnitine or ergothioneine transport, influencing susceptibility to autoimmune hypothyroidism and affecting hematological traits.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data