docosapentaenoate n3 DPA; 22:5n3 to myristoylcarnitine (c14)

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.165
Position:
131690241
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-10.450
Reference Allele:
G
-log10(P):
-57.179
MAF:
0.373
Beta (Num):
-0.059
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.106
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.8[1], 9[2]

Ratio Explanation:

The ratio reflects the balance between omega-3 fatty acid availability (docosapentaenoate) and the transport of other fatty acids (myristoylcarnitine) via the SLC22A5-mediated carnitine shuttle for energy production.1[1], 4[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in SLC22A4/A5 alters transporter function, affecting carnitine-dependent energy metabolism and possibly inflammatory responses, given SLC22A4's link to inflammation.10[1], 11[2] This likely underlies the observed changes in hematological traits like neutrophil and platelet counts and levels of the inflammatory marker uric acid.12[3], 13[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data