myristoleoylcarnitine (c14:1)* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs273917

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.133
Position:
131659618
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
7.873
Reference Allele:
G
-log10(P):
-33.301
MAF:
0.295
Beta (Num):
0.074
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.059
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 SLC22A5 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1], 7[2]

Denominator Metabolite Explanation:

Omega-6 fatty acid metabolism.8[1], 9[2]

Ratio Explanation:

This ratio reflects carnitine-dependent fatty acid transport via SLC22A5 relative to an omega-6 fatty acid, indicating cellular carnitine shuttle efficiency.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function likely disrupts carnitine-dependent energy metabolism, which is crucial for immune cell function and hematopoiesis. This disruption can lead to the observed variations in monocyte, platelet, and white blood cell counts.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data