carnitine C18:2 to dodecadienoate (12:2)*

Numerator Metabolite

Structure of linoleoylcarnitine (c18:2)*
Metabolite Accession: GCST90199916
Name: linoleoylcarnitine (c18:2)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Denominator Metabolite

Metabolite Accession: GCST90200190
Name: dodecadienoate (12:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs441969

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.163
Position:
131702120
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
10.201
Reference Allele:
A
-log10(P):
-54.587
MAF:
0.376
Beta (Num):
0.122
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.040
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle

Denominator Metabolite Explanation:

Fatty acid metabolism, Dicarboxylic acid metabolism

Ratio Explanation:

The ratio of an acylcarnitine to a dicarboxylic acid may reflect alterations in fatty acid oxidation, potentially influenced by SLC22A5-mediated carnitine transport.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine uptake, affecting fatty acid oxidation and leading to changes in hematological indices and other traits.4[1], 5[2], 6[3], 7[4], 8[5], 9[6], 10[7] This aligns with the gene's known role in systemic carnitine deficiency, which has wide-ranging metabolic consequences.1[8], 2[9], 11[10], 12[11]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data