myristoleate (14:1n5) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs273917

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.119
Position:
131659618
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-9.392
Reference Allele:
G
-log10(P):
-46.582
MAF:
0.294
Beta (Num):
-0.028
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.091
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 SLC22A5 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.5[1], 6[2]

Ratio Explanation:

This ratio may reflect carnitine-dependent fatty acid oxidation. Reduced SLC22A5 function likely decreases palmitoleoylcarnitine, thus increasing the ratio relative to myristoleate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the SLC22A5 carnitine transporter likely alters systemic carnitine levels and energy metabolism.7[1], 8[2] This may impact the production and function of hematopoietic cells, leading to observed associations with monocyte, platelet, and other blood cell counts.9[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data