docosadienoate (22:2n6) to n-palmitoylglycine

Numerator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.368
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-22.858
Reference Allele:
C
-log10(P):
-264.608
MAF:
0.208
Beta (Num):
-0.032
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.254
Position:
211540507
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-17.782
Reference Allele:
C
-log10(P):
-161.200
MAF:
0.310
Beta (Num):
-0.007
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis / elongation.8[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid amide metabolism / N-acyl-glycine degradation.12[1], 6[2], 11[3]

Ratio Explanation:

Reduced FAAH activity decreases the degradation of its substrate n-palmitoylglycine, while docosadienoate levels are likely unaffected, leading to an altered ratio reflecting FAAH function.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant reducing FAAH function increases substrate levels like N-palmitoylglycine. FAAH activity is directly implicated in renal fibrogenesis, a key process in chronic kidney disease, and FAAH inhibition has been shown to be protective in kidney injury models.14[1], 15[2], 16[3]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data