Infomap Cluster 140

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 histidineserine
Whole Blood SLC7A6 1.54e-05 histidineserine
Thyroid PLA2G15 3.73e-05 histidineserine

Genomic Context

Displaying 2 SNPs on Chr 2 for Cluster 140.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

150

Metabolite Ratios (rQTLs)

91

Total Unique Metabolites

13

Unnamed Metabolites

Ratios in Cluster 140

Ratio Name Novel in Cluster Driven By
(16 or 17)-methylstearate (a19:0 or i19:0) to n-palmitoylglycine No
(s)-3-hydroxybutyrylcarnitine to 2-butenoylglycine No
(s)-3-hydroxybutyrylcarnitine to 3-hydroxybutyroylglycine** No
1-ribosyl-imidazoleacetate* to x-24757 Yes
1-ribosyl-imidazoleacetate* to x-24795 No
1-ribosyl-imidazoleacetate* to x-25422 Yes
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to creatinine Yes
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to glycine conjugate of c10h14o2 (1)* Yes
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to glycocholenate sulfate* Yes
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to isobutyrylglycine No
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to isovalerylglycine No
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to n-acetylglucosaminylasparagine Yes
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to n-acetylputrescine Yes
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to x-21467 No
2,3-dihydroxy-5-methylthio-4-pentenoate (dmtpa)* to x-25422 Yes
2-butenoylglycine to betaine No
2-butenoylglycine to glutamine conjugate of c6h10o2 (1)* No
2-butenoylglycine to glutamine conjugate of c6h10o2 (2)* No
2-butenoylglycine to glutamine conjugate of c7h12o2* No
2-butenoylglycine to homoarginine No
2-butenoylglycine to x-25420 No
2r,3r-dihydroxybutyrate to 2-butenoylglycine No
2r,3r-dihydroxybutyrate to 3-methylglutarylcarnitine (2) No
2r,3r-dihydroxybutyrate to glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* No
2r,3r-dihydroxybutyrate to hexanoylglycine No
2r,3r-dihydroxybutyrate to isobutyrylglycine No
2r,3r-dihydroxybutyrate to isovalerylglycine No
2r,3r-dihydroxybutyrate to n-palmitoylglycine No
2r,3r-dihydroxybutyrate to serine No
2r,3r-dihydroxybutyrate to trans-2-hexenoylglycine No
2r,3r-dihydroxybutyrate to x-17325 No
2r,3r-dihydroxybutyrate to x-17367 No
2r,3r-dihydroxybutyrate to x-21467 No
2r,3r-dihydroxybutyrate to x-24757 No
2r,3r-dihydroxybutyrate to x-24795 No
2r,3r-dihydroxybutyrate to x-25422 No
3-hydroxybutyroylglycine** to glutamine conjugate of c6h10o2 (1)* No
3-hydroxybutyroylglycine** to homoarginine No
3-hydroxybutyroylglycine** to x-12101 No
3-hydroxyhexanoylcarnitine (1) to 2-butenoylglycine No
3-hydroxyhexanoylcarnitine (1) to 3-hydroxybutyroylglycine** No
3-hydroxyhexanoylcarnitine (1) to trans-2-hexenoylglycine No
3-methylglutaconate to 2r,3r-dihydroxybutyrate No
3-methylglutaconate to homoarginine No
3-methylglutarylcarnitine (2) to betaine No
3-methylglutarylcarnitine (2) to homoarginine No
5-methylthioadenosine (mta) to 3-methylglutarylcarnitine (2) No
5-methylthioadenosine (mta) to creatinine Yes
5-methylthioadenosine (mta) to glycocholenate sulfate* Yes
5-methylthioadenosine (mta) to glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* No
5-methylthioadenosine (mta) to isobutyrylglycine No
5-methylthioadenosine (mta) to isovalerylglycine No
5-methylthioadenosine (mta) to n-acetylputrescine Yes
5-methylthioadenosine (mta) to x-17325 No
5-methylthioadenosine (mta) to x-17367 No
5-methylthioadenosine (mta) to x-21467 No
5-methylthioadenosine (mta) to x-24757 Yes N/A
5-methylthioadenosine (mta) to x-24795 No
5-methylthioadenosine (mta) to x-25422 Yes
arginine to glycocholenate sulfate* Yes
arginine to guanidinoacetate Yes
arginine to serine No
asparagine to x-24757 Yes
betaine to x-17325 No
betaine to x-21467 No
betaine to x-24757 No
betaine to x-24795 No
butyrylglycine to 2r,3r-dihydroxybutyrate No
butyrylglycine to betaine No
butyrylglycine to homoarginine No
butyrylglycine to threonine No
butyrylglycine to x-25420 No
choline to glycocholenate sulfate* Yes
choline to glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* No
choline to isovalerylglycine No
choline to n-acetylputrescine Yes
choline to x-21467 No
choline to x-24757 Yes
choline to x-24795 No
choline to x-25422 Yes
cinnamoylglycine to 2r,3r-dihydroxybutyrate No
cinnamoylglycine to betaine No
cinnamoylglycine to homoarginine No
cinnamoylglycine to x-25420 No
cis 3,4-methyleneheptanoate to cis-3,4-methyleneheptanoylglycine No
cis 3,4-methyleneheptanoate to glycine conjugate of c10h12o2* Yes
cis 3,4-methyleneheptanoate to glycine conjugate of c10h14o2 (1)* Yes
cis 3,4-methyleneheptanoate to glycocholenate sulfate* Yes
cis 3,4-methyleneheptanoate to x-21467 No
cis-3,4-methyleneheptanoylcarnitine to cis-3,4-methyleneheptanoylglycine No
cis-3,4-methyleneheptanoylcarnitine to glycine conjugate of c10h12o2* Yes
cis-3,4-methyleneheptanoylcarnitine to glycine conjugate of c10h14o2 (1)* Yes
cis-3,4-methyleneheptanoylcarnitine to x-21467 No
cis-3,4-methyleneheptanoylcarnitine to x-25422 Yes
cis-3,4-methyleneheptanoylglycine to homoarginine No
cis-3,4-methyleneheptanoylglycine to x-11478 No
cis-3,4-methyleneheptanoylglycine to x-15486 No
creatine to 2r,3r-dihydroxybutyrate No
creatine to betaine No
creatine to homoarginine No
creatine to threonine No
creatinine to glutarylcarnitine (c5-dc) Yes
creatinine to kynurenate Yes
creatinine to n-acetylthreonine Yes
dihomo-linoleate (20:2n6) to n-palmitoylglycine No
dihomo-linolenate (20:3n3 or n6) to n-palmitoylglycine No
dihomo-linolenoyl-choline to sphingomyelin (d18:2/21:0, d16:2/23:0)* Yes
docosadienoate (22:2n6) to n-palmitoylglycine No
formiminoglutamate to x-25422 Yes
gamma-glutamylhistidine to isobutyrylglycine No
gamma-glutamylhistidine to isovalerylglycine No
gamma-glutamylhistidine to x-17325 No
gamma-glutamylhistidine to x-24757 Yes
gamma-glutamylhistidine to x-24795 No
gamma-glutamylthreonine to serine No
gamma-glutamylthreonine to x-25422 Yes
glutamine conjugate of c6h10o2 (2)* to 3-hydroxybutyroylglycine** No
glutamine conjugate of c7h12o2* to 3-hydroxybutyroylglycine** No
glutarylcarnitine (c5-dc) to x-21467 No
glutarylcarnitine (c5-dc) to x-24757 Yes
glutarylcarnitine (c5-dc) to x-24795 No
glutarylcarnitine (c5-dc) to x-25422 Yes
glycine conjugate of c10h14o2 (1)* to x-11478 Yes
glycine conjugate of c10h14o2 (1)* to x-14939 Yes
glycine conjugate of c10h14o2 (1)* to x-15486 Yes
glycocholenate sulfate* to 1-ribosyl-imidazoleacetate* Yes
glycocholenate sulfate* to 3b-hydroxy-5-cholenoic acid Yes
glycocholenate sulfate* to glutarylcarnitine (c5-dc) Yes
glycocholenate sulfate* to n-acetylthreonine Yes
glycocholenate sulfate* to threonine No
glycocholenate sulfate* to x-25420 No
glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* to betaine No
glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* to glutarylcarnitine (c5-dc) No
glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* to threonine No
glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* to x-25420 No
guanidinoacetate to asparagine Yes
guanidinoacetate to threonine No
hexanoylglutamine to hexanoylglycine No
hexanoylglycine to betaine No
hexanoylglycine to homoarginine No
histidine to glycocholenate sulfate* Yes
histidine to isobutyrylglycine No
histidine to isovalerylglycine No
histidine to serine No
histidine to x-24757 Yes
homoarginine to n-acetylglycine No
homoarginine to serine No
homoarginine to x-17325 No
homoarginine to x-21467 No
hydantoin-5-propionate to isovalerylglycine No
isobutyrylcarnitine (c4) to isobutyrylglycine No
isobutyrylglycine to betaine No
isobutyrylglycine to glutarylcarnitine (c5-dc) No
isobutyrylglycine to homoarginine No
isobutyrylglycine to kynurenate No
isobutyrylglycine to n-acetylthreonine No
isobutyrylglycine to threonine No
isobutyrylglycine to x-25420 No
isovalerylglycine to asparagine No
isovalerylglycine to betaine No
isovalerylglycine to homoarginine No
isovalerylglycine to kynurenate No
isovalerylglycine to n-acetylthreonine No
isovalerylglycine to threonine No
isovalerylglycine to x-23739 No
isovalerylglycine to x-25420 No
kynurenate to x-25422 Yes
linoleate (18:2n6) to n-palmitoylglycine No
myristoleate (14:1n5) to n-palmitoylglycine No
n-acetylglucosaminylasparagine to 5-methylthioadenosine (mta) Yes
n-acetylputrescine to 1-ribosyl-imidazoleacetate* Yes
n-acetylputrescine to 2r,3r-dihydroxybutyrate No
n-acetylthreonine to x-21467 No
n-acetylthreonine to x-24757 Yes
n-acetylthreonine to x-24795 No
n-acetylthreonine to x-25422 Yes
n-palmitoylglycine to 10-heptadecenoate (17:1n7) No
n-palmitoylglycine to 10-nonadecenoate (19:1n9) No
n-palmitoylglycine to 2-hydroxypalmitate No
n-palmitoylglycine to betaine No
n-palmitoylglycine to eicosenoate (20:1) No
n-palmitoylglycine to homoarginine No
n-palmitoylglycine to margarate (17:0) No
n-palmitoylglycine to myristate (14:0) No
n-palmitoylglycine to nonadecanoate (19:0) No
n-palmitoylglycine to palmitate (16:0) No
n-palmitoylglycine to palmitoleate (16:1n7) No
n-palmitoylglycine to pentadecanoate (15:0) No
n-palmitoylglycine to stearate (18:0) No
oleate/vaccenate (18:1) to n-palmitoylglycine No
oleoyl ethanolamide to n-palmitoylglycine No
picolinate to glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* No
picolinate to isobutyrylglycine No
picolinate to isovalerylglycine No
picolinate to x-24757 Yes
picolinate to x-24795 No
picolinate to x-25422 Yes
propionylglycine to 2r,3r-dihydroxybutyrate No
propionylglycine to betaine No
propionylglycine to homoarginine No
serine to asparagine No
serine to betaine No
serine to threonine No
serine to x-25420 No
sphingomyelin (d18:2/21:0, d16:2/23:0)* to glutarylcarnitine (c5-dc) Yes
taurocholenate sulfate* to glycocholenate sulfate* Yes
taurocholenate sulfate* to glycosyl-n-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2oh))* No
taurocholenate sulfate* to sphingomyelin (d18:2/21:0, d16:2/23:0)* Yes
taurocholenate sulfate* to x-21467 No
taurocholenate sulfate* to x-24757 Yes
taurocholenate sulfate* to x-24795 No
taurolithocholate 3-sulfate to glycolithocholate sulfate* Yes
threonine to x-21467 No
threonine to x-24757 No
threonine to x-24795 No
trans-2-hexenoylglycine to betaine No
trans-2-hexenoylglycine to glutamine conjugate of c6h10o2 (1)* No
trans-2-hexenoylglycine to glutamine conjugate of c6h10o2 (2)* No
trans-2-hexenoylglycine to glutamine conjugate of c7h12o2* No
trans-2-hexenoylglycine to homoarginine No
trans-2-hexenoylglycine to x-25420 No
x-17325 to hippurate No
x-17325 to threonine No
x-17325 to x-25420 No
x-17367 to betaine No
x-17367 to glutarylcarnitine (c5-dc) No
x-17367 to hippurate No
x-17367 to homoarginine No
x-17367 to threonine No
x-17367 to x-25420 No
x-24812 to x-24757 Yes
x-24812 to x-24795 No
x-24812 to x-25422 Yes
x-25420 to x-21467 No
x-25420 to x-24757 No
x-25420 to x-24795 No
x-25422 to x-25420 No