n-palmitoylglycine to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.354
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
22.587
Reference Allele:
C
-log10(P):
-258.425
MAF:
0.208
Beta (Num):
0.336
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.018
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.252
Position:
211540507
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
18.163
Reference Allele:
C
-log10(P):
-168.081
MAF:
0.310
Beta (Num):
0.247
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.005
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism1[1], 2[2]

Denominator Metabolite Explanation:

Fatty acid metabolism6[1], 7[2], 8[3], 9[4]

Ratio Explanation:

The ratio may reflect the balance between fatty acid amide degradation by FAAH and fatty acid metabolism, but a direct link is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in FAAH could alter its function, impacting N-palmitoylglycine levels.10[1], 11[2], 12[3], 13[4] Both altered FAAH function and CPS1 variants are independently associated with cholelithiasis and phenotypes related to kidney function, suggesting the genes, not the ratio, are the primary drivers.14[5], 15[6], 16[7], 17[8], 18[9], 19[10], 20[11], 21[12], 22[13], 23[14]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data