trans-2-hexenoylglycine to homoarginine

Numerator Metabolite

Structure of trans-2-hexenoylglycine
Metabolite Accession: GCST90200160
Name: trans-2-hexenoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: AAPHATPOQGNLOZ

Denominator Metabolite

Structure of homoarginine
Metabolite Accession: GCST90199675
Name: homoarginine
Hmdb Id: HMDB0000670
Super Pathway: NA
Sub Pathway: NA
Inchikey: QUOGESRFPZDMMT

Associated Genomic Regions

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.513
Position:
211540507
SE (Ratio):
0.026
Effect Allele:
A
Z-score (Ratio):
19.799
Reference Allele:
C
-log10(P):
-199.206
MAF:
0.324
Beta (Num):
0.246
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.267
SE (Den):
0.015
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Oxidation, Glycine Conjugation

Denominator Metabolite Explanation:

Urea Cycle, Amino Acid Metabolism6[1], 7[2]

Ratio Explanation:

The ratio may reflect mitochondrial dysfunction, where impaired urea cycle function (CPS1/homoarginine) is linked with altered short-chain fatty acid metabolism (trans-2-hexenoylglycine).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired CPS1 function disrupts the urea cycle, impacting nitrogen metabolism (homoarginine) and mitochondrial health, which likely contributes to renal dysfunction.8[1], 9[2], 10[3] Low homoarginine itself is a risk factor for chronic kidney disease progression, compounding this effect.8[4], 9[5], 11[6]

Phenotype Driver:

Gene-centric:CPS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data