cis-3,4-methyleneheptanoylglycine to x-15486

Numerator Metabolite

Metabolite Accession: GCST90200274
Name: cis-3,4-methyleneheptanoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200533
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.188
Position:
46870761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
10.473
Reference Allele:
C
-log10(P):
-57.421
MAF:
0.209
Beta (Num):
0.136
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.052
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Missense Variants in LD (with rs324420)

Variant Gene LD (R²) Location Consequence
rs6979 ACD 0.24 16:67691668 Missense Variant
rs6979 ACD 0.24 16:67691668 Missense Variant

eQTL Colocalization

Exposure Gene P(alpha) P(IVW) Coloc H4 Coloc (SuSiE) Plot
SLC7A6 0.116 0.001 0.978 0.007
TRADD 0.376 0.003 4.72e-10 0.989
E2F4 0.572 NA 0.015 0.989
ACD 0.760 5.99e-04 2.19e-23 0.990
FAM65A 0.941 0.025 7.94e-25 0.997

pQTL Colocalization

Exposure Protein P(alpha) P(IVW) Coloc H4 Coloc (SuSiE) Plot
SMPD3 0.006 9.53e-30 0.991 NA

GTEx eQTL Colocalization

Tissue Exposure Gene P(alpha) P(IVW) Coloc H4 Coloc (SuSiE) Plot
Heart Left Ventricle NFATC3 1.10e-05 5.43e-21 0.985 0.969
Whole Blood SLC7A6 1.54e-05 1.18e-13 0.290 1.000
Thyroid PLA2G15 3.73e-05 1.89e-25 0.992 0.999
Esophagus Mucosa PLA2G15 5.01e-05 1.89e-25 0.990 0.976
Small Intestine Terminal Ileum NFATC3 5.20e-05 NA 0.942 NA
Esophagus Gastroesophageal Junction PRMT7 6.32e-05 5.23e-14 6.04e-14 1.000
Artery Tibial PRMT7 6.59e-05 1.18e-13 4.51e-14 1.000
Artery Tibial PLA2G15 6.77e-05 1.89e-25 0.932 0.860
Esophagus Gastroesophageal Junction NFATC3 1.14e-04 4.32e-15 0.005 1.000
Nerve Tibial PLA2G15 1.31e-04 5.80e-30 0.997 0.994
Esophagus Muscularis PLA2G15 1.36e-04 3.97e-23 0.989 0.978
Esophagus Muscularis PRMT7 1.38e-04 1.37e-13 2.77e-14 1.000
Breast Mammary Tissue PLA2G15 1.98e-04 NA 0.984 0.968
Brain Cortex SMPD3 2.26e-04 NA 0.802 NA
Brain Nucleus Accumbens Basal Ganglia NFATC3 2.47e-04 NA 0.944 NA
Colon Sigmoid PRMT7 3.20e-04 1.37e-13 3.80e-14 1.000
Adrenal Gland PLA2G15 3.28e-04 NA 0.991 0.987
Thyroid SLC7A6 3.88e-04 1.23e-17 3.06e-10 1.000
Spleen NFATC3 3.91e-04 6.32e-09 0.912 1.000
Heart Atrial Appendage NFATC3 4.72e-04 NA 0.901 NA
Pituitary NFATC3 4.76e-04 1.31e-11 0.705 0.997
Spleen SMPD3 4.90e-04 NA 0.811 NA
Thyroid PRMT7 5.29e-04 0.057 3.79e-14 1.000
Colon Sigmoid NFATC3 5.70e-04 3.88e-15 2.62e-07 1.000
Nerve Tibial NFATC3 6.00e-04 9.55e-10 2.10e-08 1.000
Colon Transverse SLC7A6 6.15e-04 1.12e-14 0.897 1.000
Nerve Tibial PRMT7 8.58e-04 7.58e-08 1.61e-14 1.000
Colon Transverse NFATC3 8.75e-04 1.89e-25 0.961 1.000
Adipose Visceral Omentum PLA2G15 9.65e-04 NA 0.992 0.986
Esophagus Mucosa NFATC3 0.001 6.17e-10 0.840 NA
Brain Nucleus Accumbens Basal Ganglia PRMT7 0.001 2.20e-13 2.61e-05 1.000
Adipose Subcutaneous PLA2G15 0.001 NA 0.948 NA
Artery Coronary PLA2G15 0.002 NA 0.890 NA
Thyroid SLC7A6OS 0.002 NA 0.886 NA
Esophagus Muscularis NFATC3 0.002 9.55e-10 0.007 1.000
Artery Coronary PRMT7 0.002 7.58e-08 3.39e-09 1.000
Whole Blood NFATC3 0.003 5.43e-21 0.297 0.999
Brain Caudate Basal Ganglia NFATC3 0.003 NA 0.835 NA
Heart Left Ventricle PLA2G15 0.003 NA 0.872 NA
Pancreas PRMT7 0.003 1.12e-14 5.19e-13 1.000
Nerve Tibial SLC7A6 0.003 6.23e-11 0.950 0.996
Adipose Visceral Omentum NFATC3 0.003 9.55e-10 0.314 0.993
Colon Transverse PRMT7 0.003 1.37e-13 3.79e-14 1.000
Stomach PRMT7 0.003 1.37e-13 6.77e-14 1.000
Skin Not Sun Exposed Suprapubic PRMT7 0.003 5.23e-14 5.52e-14 1.000
Esophagus Mucosa PRMT7 0.003 6.79e-13 2.02e-14 1.000
Adipose Subcutaneous PRMT7 0.003 7.58e-08 1.89e-14 1.000
Lung SLC7A6 0.003 3.88e-15 6.55e-04 1.000
Pancreas NFATC3 0.004 NA 0.969 0.954
Breast Mammary Tissue NFATC3 0.004 2.20e-13 0.927 0.998
Muscle Skeletal SLC7A6 0.005 NA 0.976 NA
Spleen PRMT7 0.005 1.37e-13 2.19e-11 1.000
Brain Cortex PRMT7 0.006 7.58e-08 9.27e-08 1.000
Breast Mammary Tissue PRMT7 0.006 5.23e-14 2.26e-11 1.000
Lung NFATC3 0.006 1.31e-11 0.002 1.000
Heart Atrial Appendage PLA2G15 0.007 NA 0.955 NA
Skin Sun Exposed Lower Leg PRMT7 0.007 5.23e-14 9.53e-14 1.000
Lung PRMT7 0.008 0.749 7.88e-17 1.000
Brain Cerebellum NFATC3 0.008 5.43e-21 0.984 0.977
Skin Not Sun Exposed Suprapubic NFATC3 0.008 6.17e-10 0.009 1.000
Liver PRMT7 0.009 1.37e-13 1.77e-09 1.000
Skin Sun Exposed Lower Leg PLA2G15 0.013 7.27e-12 5.24e-05 1.000
Thyroid NFATC3 0.015 6.32e-09 4.81e-09 1.000
Adipose Visceral Omentum PRMT7 0.015 1.37e-13 5.01e-14 1.000
Artery Aorta PRMT7 0.016 7.58e-08 1.15e-17 1.000
Pituitary PRMT7 0.018 1.12e-14 8.78e-07 1.000
Adipose Subcutaneous NFATC3 0.019 9.55e-10 2.47e-05 1.000
Skin Sun Exposed Lower Leg NFATC3 0.019 6.32e-09 0.990 0.172
Brain Caudate Basal Ganglia PRMT7 0.031 2.31e-14 4.24e-06 1.000
Testis PLA2G15 0.040 1.18e-13 0.004 0.998
Artery Tibial NFATC3 0.044 0.359 1.01e-15 1.000
Whole Blood PRMT7 0.045 0.670 1.27e-13 1.000
Small Intestine Terminal Ileum PRMT7 0.051 1.37e-13 2.58e-07 1.000
Vagina PRMT7 0.052 2.20e-13 0.015 1.000
Brain Cerebellum PRMT7 0.057 0.262 1.13e-05 0.996
Prostate PRMT7 0.058 5.23e-14 4.47e-09 1.000
Artery Aorta NFATC3 0.070 0.308 6.89e-08 0.999
Muscle Skeletal PRMT7 0.078 6.81e-15 2.20e-12 1.000
Brain Cerebellar Hemisphere PRMT7 0.165 0.255 8.71e-06 0.998
Brain Frontal Cortex Ba9 PRMT7 0.210 0.316 1.95e-04 0.999
Whole Blood DUS2 0.327 0.316 9.89e-24 1.000

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
2
Beta (Ratio):
0.418
Position:
211540507
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
26.751
Reference Allele:
C
-log10(P):
-361.329
MAF:
0.311
Beta (Num):
0.386
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.031
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Not available.

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data