creatinine to kynurenate

Numerator Metabolite

Structure of creatinine
Metabolite Accession: GCST90200366
Name: creatinine
Hmdb Id: HMDB0000562
Super Pathway: NA
Sub Pathway: NA
Inchikey: DDRJAANPRJIHGJ

Denominator Metabolite

Structure of kynurenate
Metabolite Accession: GCST90200454
Name: kynurenate
Hmdb Id: HMDB0000715
Super Pathway: NA
Sub Pathway: NA
Inchikey: HCZHHEIFKROPDY

Associated Genomic Regions

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.123
Position:
211540507
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
7.554
Reference Allele:
C
-log10(P):
-30.799
MAF:
0.309
Beta (Num):
0.044
Novel Locus:
Yes ✔️
SE (Num):
0.014
Beta (Den):
-0.079
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
5.0
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Creatine-phosphate metabolism5[1], 6[2]

Denominator Metabolite Explanation:

Tryptophan metabolism7[1], 8[2]

Ratio Explanation:

The ratio may reflect kidney function and inflammatory status, as CPS1 variants are linked to kidney disease and kynurenate levels are altered in inflammation.9[1], 10[2], 11[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

CPS1 variants are associated with chronic kidney disease and renal failure.9[1] Impaired CPS1 function can lead to hyperammonemia, affecting renal function, while both creatinine and kynurenate are independently associated with kidney function and inflammation, which are characteristics of cholelithiasis.9[2], 11[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:CPS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data