n-palmitoylglycine to pentadecanoate (15:0)

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of pentadecanoate (15:0)
Metabolite Accession: GCST90200457
Name: pentadecanoate (15:0)
Hmdb Id: HMDB0000826
Super Pathway: NA
Sub Pathway: NA
Inchikey: WQEPLUUGTLDZJY

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.342
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
21.524
Reference Allele:
C
-log10(P):
-234.938
MAF:
0.208
Beta (Num):
0.336
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.007
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.249
Position:
211540507
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
17.647
Reference Allele:
C
-log10(P):
-158.816
MAF:
0.310
Beta (Num):
0.247
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.002
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide biosynthesis, N-acyl-alpha amino acid metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, odd-chain fatty acid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects FAAH activity; lower FAAH function increases the N-palmitoylglycine numerator, while the denominator, pentadecanoate, is a dietary fatty acid not directly metabolized by FAAH.11[1], 12[2], 13[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by an elevated ratio, is linked to altered endocannabinoid signaling, which has protective effects against renal fibrogenesis and chronic kidney disease progression.14[1], 15[2], 16[3]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data