oleate/vaccenate (18:1) to n-palmitoylglycine

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.368
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-22.564
Reference Allele:
C
-log10(P):
-257.919
MAF:
0.209
Beta (Num):
-0.033
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.243
Position:
211540507
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-16.793
Reference Allele:
C
-log10(P):
-144.055
MAF:
0.310
Beta (Num):
0.004
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis7[1], 8[2], 9[3], 10[4], 11[5]

Denominator Metabolite Explanation:

Fatty acid amide metabolism4[1], 1[2], 12[3]

Ratio Explanation:

The ratio may reflect altered FAAH activity, where decreased function could lead to lower oleate/vaccenate due to reduced substrate availability for other pathways and increased n-palmitoylglycine.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by the missense variant, may lead to elevated levels of N-palmitoylglycine. This alteration in fatty acid amide signaling could contribute to the pathogenesis of cholelithiasis and chronic kidney disease, potentially through inflammatory or fibrotic pathways.13[1], 14[2], 15[3]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data