oleoyl ethanolamide to n-palmitoylglycine

Numerator Metabolite

Structure of oleoyl ethanolamide
Metabolite Accession: GCST90200299
Name: oleoyl ethanolamide
Hmdb Id: HMDB0002088
Super Pathway: NA
Sub Pathway: NA
Inchikey: BOWVQLFMWHZBEF

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.261
Position:
211540507
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-19.353
Reference Allele:
C
-log10(P):
-190.458
MAF:
0.310
Beta (Num):
-0.014
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid signaling, fatty acid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid amide metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio signifies a balance in fatty acid amide signaling molecules; however, `CPS1` is not directly involved, implying an indirect systemic metabolic link.1[1], 5[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired `CPS1` function disrupts the urea cycle, leading to nitrogen imbalance and systemic metabolic stress that can affect liver and kidney function, manifesting as cholelithiasis and renal disease, and altering circulating fatty acid amide levels.4[1], 11[2], 12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:CPS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data