n-palmitoylglycine to eicosenoate (20:1)

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.373
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
22.299
Reference Allele:
C
-log10(P):
-251.966
MAF:
0.208
Beta (Num):
0.336
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.037
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.251
Position:
211540507
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
16.943
Reference Allele:
C
-log10(P):
-146.593
MAF:
0.310
Beta (Num):
0.247
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.004
SE (Den):
0.017
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide biosynthesis/degradation

Denominator Metabolite Explanation:

Fatty acid elongation and metabolism.7[1]

Ratio Explanation:

An increased ratio suggests reduced FAAH activity, leading to accumulation of n-palmitoylglycine relative to eicosenoate, potentially impacting inflammatory and metabolic pathways.8[1], 9[2], 10[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH function due to genetic variants increases n-palmitoylglycine. Altered levels of these lipids are linked to inflammation and metabolic dysregulation, which may contribute to cholelithiasis and chronic kidney disease, conditions with inflammatory components.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data