n-palmitoylglycine to palmitate (16:0)

Numerator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.357
Position:
46870761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
23.749
Reference Allele:
C
-log10(P):
-285.412
MAF:
0.208
Beta (Num):
0.336
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.022
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.249
Position:
211540507
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
18.642
Reference Allele:
C
-log10(P):
-176.909
MAF:
0.310
Beta (Num):
0.247
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.002
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid amide metabolism.1[1], 3[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.4[1]

Ratio Explanation:

The ratio of n-palmitoylglycine to palmitate reflects the activity of FAAH, where a lower ratio indicates higher FAAH activity and vice versa.1[1], 3[2], 2[3]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by an elevated n-palmitoylglycine to palmitate ratio, is associated with cholelithiasis and markers of renal dysfunction.5[1], 6[2], 7[3], 8[4] Altered FAAH function likely drives these phenotypes by disrupting lipid signaling.

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data