hexanoylglutamine to hexanoylglycine

Numerator Metabolite

Structure of hexanoylglutamine
Metabolite Accession: GCST90199833
Name: hexanoylglutamine
Hmdb Id: HMDB0242182
Super Pathway: NA
Sub Pathway: NA
Inchikey: NONGMLDQXRDGIT

Denominator Metabolite

Structure of hexanoylglycine
Metabolite Accession: GCST90199781
Name: hexanoylglycine
Hmdb Id: HMDB0000701
Super Pathway: NA
Sub Pathway: NA
Inchikey: UPCKIPHSXMXJOX

Associated Genomic Regions

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.348
Position:
211540507
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-18.273
Reference Allele:
C
-log10(P):
-170.086
MAF:
0.309
Beta (Num):
-0.023
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.326
SE (Den):
0.019
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, specifically acyl-amino acid conjugation for detoxification.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid metabolism, specifically acyl-glycine conjugation for detoxification.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the relative availability of glutamine versus glycine for conjugation with hexanoyl-CoA, a process influenced by CPS1's role in nitrogen metabolism.2[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced CPS1 function can alter nitrogen balance and glutamine availability, impacting the hexanoylglutamine/hexanoylglycine ratio; this metabolic dysregulation is associated with cholelithiasis and renal disease, conditions linked to CPS1 variants.3[1], 12[2], 13[3], 14[4], 15[5]

Phenotype Driver:

Gene-centric:[CPS1]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data