(16 or 17)-methylstearate (a19:0 or i19:0) to n-palmitoylglycine

Numerator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.353
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-22.609
Reference Allele:
C
-log10(P):
-258.940
MAF:
0.208
Beta (Num):
-0.018
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.256
Position:
211540507
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-18.533
Reference Allele:
C
-log10(P):
-174.884
MAF:
0.310
Beta (Num):
-0.009
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid amide metabolism.4[1], 9[2]

Ratio Explanation:

The ratio reflects FAAH activity; lower FAAH function leads to accumulation of the N-palmitoylglycine denominator, causing the ratio to decrease.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by a lower ratio, is linked to cholelithiasis and chronic kidney disease.10[1], 11[2] In the kidney, FAAH inactivation is protective against renal fibrogenesis, suggesting a complex role in renal pathology.10[3], 12[4], 13[5]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data