taurolithocholate 3-sulfate to glycolithocholate sulfate*

Numerator Metabolite

Structure of taurolithocholate 3-sulfate
Metabolite Accession: GCST90199809
Name: taurolithocholate 3-sulfate
Hmdb Id: HMDB0002580
Super Pathway: NA
Sub Pathway: NA
Inchikey: HSNPMXROZIQAQD

Denominator Metabolite

Structure of glycolithocholate sulfate*
Metabolite Accession: GCST90199811
Name: glycolithocholate sulfate*
Hmdb Id: HMDB0002639
Super Pathway: NA
Sub Pathway: NA
Inchikey: FHXBAFXQVZOILS

Associated Genomic Regions

Region: rs1047891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.114
Position:
211540507
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-8.788
Reference Allele:
C
-log10(P):
-41.022
MAF:
0.309
Beta (Num):
-0.062
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.052
SE (Den):
0.017
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Bile acid biosynthesis3[1], 4[2], 5[3], 6[4]

Denominator Metabolite Explanation:

Bile acid biosynthesis7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects differential sulfation of lithocholate conjugates; taurolithocholate and glycolithocholate are both products of lithocholic acid conjugation before sulfation.3[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

CPS1 variants may alter nitrogen metabolism, impacting liver function, including bile acid conjugation and sulfation, potentially contributing to cholelithiasis and kidney disease.10[1], 1[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:CPS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data