dihomo-linoleate (20:2n6) to n-palmitoylglycine

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.365
Position:
46870761
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-23.552
Reference Allele:
C
-log10(P):
-280.742
MAF:
0.208
Beta (Num):
-0.030
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.243
Position:
211540507
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-17.641
Reference Allele:
C
-log10(P):
-158.700
MAF:
0.309
Beta (Num):
0.004
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism, Biosynthesis of unsaturated fatty acids.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, N-acyl-alpha amino acid metabolism.8[1], 9[2]

Ratio Explanation:

An increased ratio suggests decreased FAAH activity, leading to accumulation of the substrate N-palmitoylglycine and altered fatty acid metabolism, potentially affecting dihomo-linoleate levels.10[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced FAAH activity due to the missense variant increases its substrate, N-palmitoylglycine, and can lead to kidney damage.1[1], 12[2] Inactivation of FAAH has been shown to protect against renal fibrogenesis, linking the gene to the chronic kidney disease phenotype.13[3], 12[4]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data