myristoleate (14:1n5) to n-palmitoylglycine

Numerator Metabolite

Structure of myristoleate (14:1n5)
Metabolite Accession: GCST90199715
Name: myristoleate (14:1n5)
Hmdb Id: HMDB0002000
Super Pathway: NA
Sub Pathway: NA
Inchikey: YWWVWXASSLXJHU

Denominator Metabolite

Structure of n-palmitoylglycine
Metabolite Accession: GCST90199923
Name: n-palmitoylglycine
Hmdb Id: HMDB0013034
Super Pathway: NA
Sub Pathway: NA
Inchikey: KVTFEOAKFFQCCX

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.356
Position:
46870761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-20.893
Reference Allele:
C
-log10(P):
-221.536
MAF:
0.208
Beta (Num):
-0.021
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.336
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.145
Position:
102075479
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-7.864
Reference Allele:
G
-log10(P):
-33.226
MAF:
0.176
Beta (Num):
-0.097
Novel Locus:
Yes ✔️
SE (Num):
0.019
Beta (Den):
0.048
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs1047891

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.247
Position:
211540507
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-16.332
Reference Allele:
C
-log10(P):
-136.389
MAF:
0.309
Beta (Num):
-2.33e-04
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.247
SE (Den):
0.016
No CNV overlap
rQTL cluster:
140
Reaction Distance:
NA
Closest Genes:
CPS1 LANCL1 MYL1 ACADL KANSL1L

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid amide metabolism.6[1], 1[2], 7[3]

Ratio Explanation:

The ratio reflects FAAH activity; a higher ratio suggests decreased FAAH function, leading to the accumulation of N-palmitoylglycine relative to myristoleate.1[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity increases N-palmitoylglycine and other endocannabinoids, which can promote inflammation and cardiac stress, contributing to cardiovascular and metabolic diseases.9[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data